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Biochim Biophys Acta. 2000 Jun 26;1486(1):45-54.

Sterol carrier protein-2.

Author information

1
Institute for Arteriosclerosis Research, Institute for Clinical Chemistry and Laboratory Medicine, Interdisciplinary Center for Clinical Research, Westphalian Wilhelms-University, M√ľnster, Germany. seedorfu@uni-muenster.de

Abstract

The compartmentalization of cholesterol metabolism implies target-specific cholesterol trafficking between the endoplasmic reticulum, plasma membrane, lysosomes, mitochondria and peroxisomes. One hypothesis has been that sterol carrier protein-2 (SCP2, also known as the non-specific lipid transfer protein) acts in cholesterol transport through the cytoplasm. Recent studies employing gene targeting in mice showed, however, that mice lacking SCP2 and the related putative sterol carrier known as SCPx, develop a defect in peroxisomal beta-oxidation. In addition, diminished peroxisomal alpha-oxidation of phytanic acid (3,7,11, 15-tetramethylhexadecanoic acid) in these null mice was attributed to the absence of SCP2 which has a number of properties supporting a function as carrier for fatty acyl-CoAs rather than for sterols.

PMID:
10856712
DOI:
10.1016/s1388-1981(00)00047-0
[Indexed for MEDLINE]

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