Format

Send to

Choose Destination
See comment in PubMed Commons below
Pharmacotherapy. 2000 Jun;20(6):657-61.

Comparison of the serum and intracellular pharmacokinetics of azithromycin in healthy and diabetic volunteers.

Author information

1
Division of Clinical and Administrative Pharmacy, University of Iowa, College of Pharmacy, Iowa City 52242, USA.

Abstract

STUDY OBJECTIVE:

To compare serum and intracellular pharmacokinetics of azithromycin in healthy volunteers and patients with diabetes.

DESIGN:

Open-label, parallel study.

SETTING:

Clinical research center.

SUBJECTS:

Twelve patients with diabetes and 12 healthy volunteers.

INTERVENTIONS:

Subjects were given a single 500-mg dose of azithromycin followed by 250 mg/day for 2 days. Blood samples were obtained just before and after the third dose for up to 24 hours for serum and 168 hours for intracellular measurement of azithromycin.

MEASUREMENTS AND MAIN RESULTS:

Pharmacokinetic parameters were calculated by noncompartmental methods and compared with a t test. The groups did not differ in maximum concentration, time to maximum concentration, or area under the concentration-time curve in serum or polymorphonuclear cells (PMNs). Differences in the PMN:serum ratio were observed at the 24-hour time point (healthy 1209 +/- 432, diabetic 859 +/- 286, p=0.051).

CONCLUSION:

In general, the pharmacokinetics of azithromycin are comparable in diabetics and healthy volunteers. Accumulation of drug in macrophages was slightly lower in patients.

PMID:
10853621
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley
    Loading ...
    Support Center