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J Clin Endocrinol Metab. 2000 Jun;85(6):2122-6.

Osteoporosis: an unusual presentation of childhood Crohn's disease.

Author information

1
Division of Pediatric Endocrinology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA.

Abstract

Osteoporosis is known to be associated with Crohn's disease. We report a 12-yr-old boy without a history of steroid use, in whom severe osteoporosis and multiple collapsed vertebrae were the presenting manifestations of Crohn's disease. After treatment of the Crohn's disease, he resumed normal growth and progressed through puberty. Concomitantly, he demonstrated a substantial recovery of vertebral bone mineral density and structure. Possible pathophysiological mechanisms underlying the osteoporosis and the subsequent improvement in bone density are discussed.

PMID:
10852438
DOI:
10.1210/jcem.85.6.6640
[Indexed for MEDLINE]

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