Format

Send to

Choose Destination
Neuroreport. 2000 Jun 5;11(8):1769-72.

Exogenous administration of L-arginine protects cholinergic neurons from colchicine neurotoxicity.

Author information

1
Department of Veterinary Morphophysiology and Animal Production (DIMORFIPA), University of Bologna, Ozzano dell'Emilia, Italy.

Abstract

The effect of L-arginine administration on susceptibility/resistance of NO-producing neurons was investigated in non-ischemic neurodegenerative conditions. ChAT mRNA level was measured by in situ hybridization in the basal forebrain after i.c.v. colchicine administration. Colchicine induced down-regulation of ChAT mRNA level followed by degeneration of cholinergic neurons. L-Arginine treatment increased ChAT mRNA level and prevented/delayed ChAT mRNA decrease by colchicine. These data suggest that L-arginine treatment may protect cholinergic neurons from colchicine-induced degeneration.

PMID:
10852241
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wolters Kluwer
Loading ...
Support Center