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Curr Opin Neurobiol. 2000 Jun;10(3):352-7.

LTP mechanisms: from silence to four-lane traffic.

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Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.


Brief periods of strong neuronal activity induce long-lasting changes in synaptic function. This synaptic plasticity is thought to play important roles in learning and memory. One example--long-term potentation in the CA1 region of the hippocampus--has been studied extensively, and conflicting views regarding the underlying mechanisms have emerged. Recent findings, regarding basic properties of synaptic transmission, appear to reconcile these diverging views.

[Indexed for MEDLINE]

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