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Adv Exp Med Biol. 2000;477:305-15.

Ceramide as an activator lipid of cathepsin D.

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1
Institute of Immunology, University of Kiel, Germany.

Abstract

We have identified the aspartic protease cathepsin D as a novel intracellular target protein for the lipid second messenger ceramide. Ceramide specifically binds to and induces CTSD proteolytic activity. A-SMase deficient cells derived from Niemann-Pick patients show decreased CTSD activity that was reconstituted by transfection with A-SMase cDNA. Ceramide accumulation in cells derived from A-ceramidase defective Farber patients correlates with enhanced CTSD activity. These findings suggest that A-SMase-derived ceramide targets endolysosomal CTSD.

PMID:
10849758
DOI:
10.1007/0-306-46826-3_33
[Indexed for MEDLINE]
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