Solitary fibrous tumor of the vagina

Pathol Int. 2000 Apr;50(4):327-31. doi: 10.1046/j.1440-1827.2000.01042.x.

Abstract

The solitary fibrous tumor (SFT) is a rare tumor that most commonly arises in the pleura. Recent evidence has indicated that this tumor originates from mesenchymal, probably fibroblastic, cells and is not restricted to the pleura. However, its occurrence in the female genital tract is extremely rare. We report a case of primary SFT that originated from the vagina in a 34-year-old female. It was a pedunculated polypoid tumor and occurred at the site of scar tissue, caused by laceration during her last labor 7 years previously. Histologically, the tumor was predominantly composed of a random proliferation of spindle cells, intimately admixed with collagen. Immunohistochemically, the cells were strongly positive for CD34, vimentin and bcl-2, but were negative for S-100 protein, neuron-specific enolase, smooth muscle actin, desmin, CD68, cytokeratins and epithelial membrane antigen. To the best of our knowledge, this is the first reported case of a primary vaginal SFT in the English literature. Our report suggests to include SFT in the differential diagnosis of a spindle cell neoplasm originating from the vagina.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Diagnosis, Differential
  • Female
  • Humans
  • Neoplasms, Fibrous Tissue* / diagnosis
  • Neoplasms, Fibrous Tissue* / pathology
  • Neoplasms, Fibrous Tissue* / physiopathology
  • Vaginal Neoplasms* / diagnosis
  • Vaginal Neoplasms* / pathology
  • Vaginal Neoplasms* / physiopathology