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Heredity (Edinb). 2000 Apr;84 ( Pt 4):437-40.

Optimal marker density for interval mapping in a backcross population.

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Institut für Nutzpflanzenkunde, Universität Kassel, Steinstrasse 13, 37213 Witzenhausen, Germany.


An important question in QTL mapping is the optimal choice of marker density. Using analytical results, it is shown for the case of interval mapping in a backcross population, that the power of QTL detection and the standard errors of genetic effect estimates are little affected by an increase of marker density beyond 10 cM. This finding confirms published simulation results by other authors.

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