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Eur J Biochem. 2000 Jun;267(12):3395-401.

Towards a molecular understanding of polycythemia rubra vera.

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Division of Experimental Anaesthesiology, University Hospital Freiburg, Center for Tumor Biology, Germany.


Polycythemia rubra vera (PV) is one of four diseases collectively called the myeloproliferative disorders (MPDs). Each disorder leads to an increased production of one or several hematopoietic cell lineages. MPDs arise from acquired mutations in a pluripotent hematopoietic stem cell. However, the molecular mechanisms leading to the development of these diseases are poorly understood. This review will summarize and evaluate recent advances in our understanding of one particular MPD, PV.

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