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Arch Intern Med. 2000 Jun 12;160(11):1654-8.

Headache in mild-to-moderate hypertension and its reduction by irbesartan therapy.

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1
Division of Clinical Hypertension Research, Institute for Geriatrics, Uppsala Universitet, Sweden.

Abstract

BACKGROUND:

Although it is generally acknowledged to be a problem in severe hypertension, headache has not been consistently associated with mild-to-moderate hypertension.

PATIENTS AND METHODS:

In 7 randomized, double-blind, placebo-controlled trials, which included 2,673 patients with mild-to-moderate hypertension (defined as seated diastolic blood pressure of 95-110 mm Hg), patients were randomized to receive once-daily treatment with irbesartan, an angiotensin II receptor blocker (n= 1,987), or placebo (n=686). The data were pooled and analyzed retrospectively to determine whether the level of hypertension was associated with headache and whether antihypertensive therapy reduced the incidence of headache.

RESULTS:

Factors found to be predictive of headache incidence were diastolic blood pressure, sex (female), and age (<50 years). In comparison with placebo, the use of irbesartan was associated with a significant reduction in the incidence of headache (P=.003).

CONCLUSIONS:

These data suggest that mild-to-moderate hypertension is not asymptomatic and that the incidence of headache can be reduced by antihypertensive treatment with a favorable adverse effect profile.

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PMID:
10847258
[Indexed for MEDLINE]

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