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Ir J Med Sci. 2000 Jan-Mar;169(1):19-21.

Pregnancy in Irish renal transplant recipients in the cyclosporine era.

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1
Department of Nephrology, Beaumont Hospital, Dublin.

Abstract

BACKGROUND:

The effect of renal transplantation on pregnancy in Irish women not receiving CyA has been reported previously.

AIM:

To examine all pregnancies occurring in Irish female renal transplant recipients since the introduction of CyA.

METHODS:

Using a community based approach, we identified 29 pregnancies in 19 women, aged between 16 and 45, mean age 30.3 years.

RESULTS:

These pregnancies ended in four miscarriages (13%), two intra-uterine deaths (6.9%) and 23 live births (79.3%). Of these live births, 73.9% were premature (< or = 36 weeks) and 65.2% were of low birth weight (< 2500 g). Admission to the neonatal intensive care was necessary in 61%, and two babies (8.7%) died in the neonatal period. Mean gestational age was 34 weeks, and mean birth weight was 2190 g. There was no change in graft function during pregnancy, with a small rise in serum creatinine post-partum (+9.64 mumol/L). The renal graft failed in three women (15.8%) by the end of the follow-up period. Compared with the precyclosporine era, the live birth rate was higher (79.3% versus 58%) with a trend towards lower birth weight and shorter gestation.

CONCLUSION:

Renal transplantation with CyA use is not a contraindication to pregnancy, but it is associated with increased risk, especially when the serum creatinine is > 175 mumol/L.

PMID:
10846851
[Indexed for MEDLINE]
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