Format

Send to

Choose Destination
See comment in PubMed Commons below
Annu Rev Neurosci. 2000;23:73-87.

Apoptosis in neural development and disease.

Author information

1
Howard Hughes Medical Institute, University of Texas Southwestern Medical Center at Dallas 75235, USA. nijhawan.deepak@tumora.swmed.edu

Abstract

Cell death via apoptosis is a prominent feature in mammalian neural development. Recent studies into the basic mechanism of apoptosis have revealed biochemical pathways that control and execute apoptosis in mammalian cells. Protein factors in these pathways play important roles during development in regulating the balance between neuronal life and death. Additionally, mounting evidence indicates such pathways may also be activated during several neurodegenerative diseases, resulting in improper loss of neurons.

PMID:
10845059
DOI:
10.1146/annurev.neuro.23.1.73
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Atypon
    Loading ...
    Support Center