New taxanes with an opened oxetane ring from the roots of Taxus mairei

Y C Shen; K L Lo; C Y Chen; Y H Kuo; M C Hung

doi:10.1021/np990629j

New taxanes with an opened oxetane ring from the roots of Taxus mairei

J Nat Prod. 2000 May;63(5):720-2. doi: 10.1021/np990629j.

Authors

Y C Shen¹, K L Lo, C Y Chen, Y H Kuo, M C Hung

Affiliation

¹ Institute of Marine Resources, National Sun Yat-sen University, 70 Lien-Hai Road, Kaohsiung, Taiwan, Republic of China. ycshen@mail.nsysu.edu.tw

PMID: 10843601
DOI: 10.1021/np990629j

Abstract

Two novel taxoids, taxumairols N (1) and O (2), have been isolated from extracts of the roots of Taxus mairei. The structures of 1 and 2 were identified as 7beta,9alpha,10beta,13alpha-tetraacetoxy-2alp ha, 4alpha,5alpha,20-tetrahydroxytax-11-ene and 7beta,9alpha,10beta, 13alpha-tetraacetoxy-1beta,2alpha,4alpha,5alp ha, 20-pentahydroxytax-11-ene on the basis of 1D and 2D NMR techniques including COSY, HMQC, HMBC, and NOESY experiments.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Magnetic Resonance Spectroscopy
Molecular Conformation
Paclitaxel / analogs & derivatives*
Paclitaxel / chemistry
Paclitaxel / isolation & purification
Plant Roots / chemistry
Plants, Medicinal / chemistry*
Spectrometry, Mass, Fast Atom Bombardment
Spectrophotometry, Infrared
Spectrophotometry, Ultraviolet
Taxoids*
Taxus / chemistry*

Substances

Taxoids
taxumairol N
taxumairol O
Paclitaxel