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Immunity. 2000 May;12(5):483-94.

IP-10 is critical for effector T cell trafficking and host survival in Toxoplasma gondii infection.

Author information

1
Department of Medicine, Dartmouth Medical Center, Hanover, New Hampshire 03755, USA.

Abstract

The generation of an adaptive immune response against intracellular pathogens requires the recruitment of effector T cells to sites of infection. Here we show that the chemokine IP-10, a specific chemoattractant for activated T cells, controls this process in mice naturally infected with Toxoplasma gondii. Neutralization of IP-10 in infected mice inhibited the massive influx of T cells into tissues and impaired antigen-specific T cell effector functions. This resulted in >1000-fold increase in tissue parasite burden and a marked increase in mortality compared to control antibody-treated mice. These observations suggest that IP-10 may play a broader role in the localization and function of effector T cells at sites of Th1 inflammation.

PMID:
10843381
DOI:
10.1016/s1074-7613(00)80200-9
[Indexed for MEDLINE]
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