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Bioorg Med Chem Lett. 2000 May 15;10(10):1117-20.

Carbonic anhydrase inhibitors: synthesis of N-morpholylthiocarbonylsulfenylamino aromatic/heterocyclic sulfonamides and their interaction with isozymes I, II and IV.

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1
Università degli Studi, Laborarorio di Chimica Inorganica e Bioinorganica, Florence, Italy.

Abstract

Several aromatic/heterocyclic sulfonamides possessing free amino, imino or hydrazino moieties were transformed into the corresponding N-morpholylthiocarbonylsulfenyl derivatives, by reaction with N-morpholyldithiocarbamate in the presence of oxidizing agents (NaClO or iodine). These compounds showed nanomolar inhibition against three CA isozymes, and interesting in vitro tumor cell growth inhibitory properties, against several leukemia, non-small cell lung, ovarian, melanoma, colon, CNS, renal, prostate and breast cancer cell lines.

PMID:
10843231
DOI:
10.1016/s0960-894x(00)00178-5
[Indexed for MEDLINE]

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