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Bioorg Med Chem Lett. 2000 May 15;10(10):1097-100.

First pharmacophoric hypothesis for 5-HT7 antagonism.

Author information

1
Departamento de Química Orgánica I, Facultad de Ciencias Químicas, Universidad Complutense, Madrid, Spain. mluzlr@eucmax.sim.ucm.es

Abstract

In order to make the first contribution to the elucidation of essential structural features for 5-HT7 antagonism, a set of thirty 5-HT7 antagonists were selected from the literature. A pharmacophore model was built using Molecular Modeling studies with Catalyst program. The information contained in this model was validated with new synthesized compounds.

PMID:
10843226
DOI:
10.1016/s0960-894x(00)00166-9
[Indexed for MEDLINE]

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