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Bioorg Med Chem Lett. 2000 May 15;10(10):1069-72.

Bicyclic pyridones as potent, efficacious and orally bioavailable thrombin inhibitors.

Author information

1
Department of Medicinal Chemistry, Merck Research Laboratories, West Point, PA 19486, USA. craig_coburn@merck.com

Abstract

A new class of conformationally constrained thrombin inhibitors is described. These compounds contain a unique bicyclic pyridone scaffold which serves as a P3P2 dipeptide surrogate. The synthesis and antithrombotic activity of these inhibitors is reported.

PMID:
10843219
DOI:
10.1016/s0960-894x(00)00170-0
[Indexed for MEDLINE]

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