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Mech Dev. 2000 Jun;94(1-2):189-93.

XSIP1, a Xenopus zinc finger/homeodomain encoding gene highly expressed during early neural development.

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Department of Cell Growth, Differentiation and Development(VIB-07), Flanders Interuniversity Institute for Biotechnology (VIB), University of Leuven, Onderwijs en Navorsing, Belgium.


We have isolated a Xenopus homologue of the zinc finger/homeodomain-containing transcriptional repressor Smad-interacting protein-1 (SIP1) from mouse. XSIP1 is activated at the early gastrula stage and transcription occurs throughout embryogenesis. At the beginning of gastrulation, XSIP1 is strongly expressed in prospective neurectoderm. At the neurula stage, XSIP1 is highly expressed within the neural plate but weakly in the dorsal midline. At later stages of development transcripts are detected primarily within the neural tube and neural crest. In the adult, XSIP1 expression is detected at variable levels in several organs.

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