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Mech Dev. 2000 Jun;94(1-2):47-56.

Proximal distal axis formation in the Drosophila leg: distinct functions of teashirt and homothorax in the proximal leg.

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European Molecular Biology Laboratory, Heidelberg, Germany.


The proximal distal axis of the Drosophila leg is patterned by expression of a number of transcription factors in discrete domains along the axis. The homeodomain protein Homothorax and the zinc-finger protein Teashirt are broadly coexpressed in the presumptive body wall and proximal leg segments. Homothorax has been implicated in forming a boundary between proximal and distal segments of the leg. We present evidence that Teashirt is required for the formation of proximal leg segments, but has no role in boundary formation.

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