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J Biol Regul Homeost Agents. 2000 Apr-Jun;14(2):116-9.

As2O3 induces apoptosis of the human B lymphoma cell line MBC-1.

Author information

1
Department of Oncology, Shanghai Institute for Pediatric Research, China.

Abstract

OBJECTIVE:

To see how arsenic trioxide (As2O3) affects proliferation of the human B lymphoma cell line MBC-1.

METHODS:

We studied the effect of As2O3 on MBC-1 cells and its mechanism by morphological observation, flow cytometry assay and DNA gel electrophoresis.

RESULTS:

As2O3 could upregulate p53 gene expression at protein level, inducing cell apoptosis and inhibiting the proliferation of MBC-1 cells. Upregulation of p53 expression appears to be important in the apoptosis of MBC-1 cells.

CONCLUSIONS:

As2O3 can inhibit the proliferation of MBC-1 cells by upregulating p53 gene expression, thus inducing apoptosis.

PMID:
10841286
[Indexed for MEDLINE]

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