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Trends Biochem Sci. 2000 Jun;25(6):284-9.

LNB-TM7, a group of seven-transmembrane proteins related to family-B G-protein-coupled receptors.

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Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, UK OX1 3RE.


A number of unusual seven-transmembrane molecules have recently been characterized that have significant amino acid sequence similarity within the membrane-spanning hydrophobic regions and intervening loops to members of G-protein-coupled receptor family B. However, in contrast to the family-B G-protein-coupled receptors, these molecules have unusually large N-terminal extracellular domains that contain a number of well- characterized protein modules. The range of cell types expressing these complex molecules and their potential roles in cell adhesion and signalling have become a major focus of research in a number of biological systems.

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