Format

Send to

Choose Destination
Adv Drug Deliv Rev. 1997 Jul 7;26(2-3):71-90.

Delivery of molecular and cellular medicine to solid tumors.

Author information

1
Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA

Abstract

To reach cancer cells in a tumor, a blood-borne therapeutic molecule or cell must make its way into the blood vessels of the tumor and across the vessel wall into the interstitium, and finally migrate through the interstitium. Unfortunately, tumors often develop in ways that hinder each of these steps. Our research goals are to analyze each of these steps experimentally and theoretically, and then integrate the resulting information in a unified theoretical framework. This paradigm of analysis and synthesis has allowed us to obtain a better understanding of physiological barriers in solid tumors, and to develop novel strategies to exploit and/or to overcome these barriers for improved cancer detection and treatment.

PMID:
10837535

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center