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J Antimicrob Chemother. 2000 Jun;45(6):887-90.

Retrospective screening for heterogeneous vancomycin resistance in diverse Staphylococcus aureus clones disseminated in French hospitals.

Author information

1
French National Reference Centre for Staphylococci, Unité des Staphylocoques, Institut Pasteur, 28, rue du Docteur Roux, 75724 Paris Cedex 15, France.

Abstract

Twenty-five different Staphylococcus aureus strains that are widespread in France were screened by various methods for heterogeneous and low-level resistance to vancomycin. Population analysis on brain-heart infusion agar containing 4 mg/L of the drug detected resistant cells at frequencies of 10-7 to 10-6 in five multiply resistant strains. There was no antagonism between vancomycin and beta-lactam antibiotics. One of the five strains, isolated in 1993, was considered a putative progenitor of a French nosocomial S. aureus strain isolated in 1998 and for which the vancomycin MIC was 8 mg/L.

PMID:
10837445
DOI:
10.1093/jac/45.6.887
[Indexed for MEDLINE]

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