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Curr Opin Plant Biol. 2000 Jun;3(3):188-95.

Regulation of sulfate transport and synthesis of sulfur-containing amino acids.

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Laboratory of Molecular Biology and Biotechnology, Faculty of Pharmaceutical Sciences, Research Center of Medicinal Resources, Chiba University, Inage-ku, 263-8522, Japan.


Recent research indicates that several sulfate transporters - exhibiting different tissue specificities and modes of expression - may play distinct roles in sulfate uptake within specific tissues and in long-distance sulfate translocation. The transcription levels of particular genes and feedback inhibition of serine acetyltransferase play major roles in regulating sulfur assimilation and cysteine synthesis. O-acetylserine and glutathione presumably act within the cysteine synthesis pathway as derepressor and repressor, respectively. A unique autoregulatory mechanism that stabilizes mRNA levels has recently been proposed for the regulation of methionine synthesis.

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