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Nat Genet. 2000 Jun;25(2):147-52.

Computer-based three-dimensional visualization of developmental gene expression.

Author information

1
Integrative Morphology Group, Department of Anatomy, University of Vienna, Vienna, Austria. johannes.streicher@univie.ac.at

Abstract

A broad understanding of the relationship between gene activation, pattern formation and morphogenesis will require adequate tools for three-dimensional and, perhaps four-dimensional, representation and analysis of molecular developmental processes. We present a novel, computer-based method for the 3D visualization of embryonic gene expression and morphological structures from serial sections. The information from these automatically aligned 3D reconstructions exceeds that from single-section and whole-mount visualizations of in situ hybridizations. In addition, these 3D models of gene-expression patterns can become a central component of a future developmental database designed for the collection and presentation of digitized, morphological and gene-expression data. This work is accompanied by a web site (http://www.univie.ac.at/GeneEMAC).

PMID:
10835627
DOI:
10.1038/75989
[Indexed for MEDLINE]
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