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Exp Gerontol. 2000 May;35(3):317-29.

Tumor suppressors and oncogenes in cellular senescence.

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Department of Immunology and Oncology, National Center of Biotechnology, E-28049, Cantoblanco, Madrid, Spain.


Cyclin-dependent kinase inhibitors p16(INK4a), p21(Cip1), and p27(Kip1) are regarded as key effectors of cellular senescence. In this review, we describe three senescence-inducing pathways involving these inhibitors, namely, the p16(INK4a)/Rb pathway, the p19(ARF)/p53/p21(Cip1) pathway, and the PTEN/p27(Kip1) pathway. We emphasize the participation of tumor suppressors and oncogenes in the regulation of these senescence-inducing pathways. Finally, we discuss the impact of the Ras and Myc oncogenes on the above-mentioned pathways.

[Indexed for MEDLINE]

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