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Dermatology. 2000;200(3):244-6.

Strontium nitrate decreased histamine-induced itch magnitude and duration in man.

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1
Department of Dermatology, School of Medicine, University of California, San Francisco, Calif. 94143-0989, USA.

Abstract

BACKGROUND:

Previous studies have demonstrated that strontium salts have a potent and broad ability to suppress sensory irritation.

OBJECTIVE:

To ascertain the possible antipruritic effects of topical strontium salts, we conducted a double-blind randomized study to evaluate the effect of 20% strontium nitrate on itch magnitude (intensity) and duration.

METHODS:

In 8 human subjects, strontium nitrate was applied to the volar forearm and vehicle control to the contralateral volar forearm for 30 min; both substances were reapplied for an additional 5 min. Itch was then experimentally induced by intradermal injection of histamine. Itch magnitude was rated each minute for the first 20 min using a visual analogue scale (VAS). Itch duration in minutes was also recorded.

RESULTS:

Strontium nitrate, in comparison to its vehicle control, significantly shortened itch duration from 28.1+/-5.4 min (mean +/- SEM) to 18.5+/-4.2 min (p<0.01) and reduced itch magnitude at time points 12-20 min and overall (p<0.05).

CONCLUSION:

Strontium nitrate may act as a topical antipruritic agent in reducing histamine-mediated itch.

PMID:
10828634
DOI:
18367
[Indexed for MEDLINE]
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