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Biophys J. 2000 Jun;78(6):2798-813.

The mechanochemistry of V-ATPase proton pumps.

Author information

1
Departments of Physics, University of California, Berkeley 94720-3112, USA.

Abstract

The vacuolar H(+)-ATPases (V-ATPases) are a universal class of proton pumps that are structurally similar to the F-ATPases. Both protein families are characterized by a membrane-bound segment (V(o), F(o)) responsible for the translocation of protons, and a soluble portion, (V(1), F(1)), which supplies the energy for translocation by hydrolyzing ATP. Here we present a mechanochemical model for the functioning of the V(o) ion pump that is consistent with the known structural features and biochemistry. The model reproduces a variety of experimental measurements of performance and provides a unified view of the many mechanisms of intracellular pH regulation.

PMID:
10827963
PMCID:
PMC1300868
DOI:
10.1016/S0006-3495(00)76823-8
[Indexed for MEDLINE]
Free PMC Article

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