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Trends Genet. 2000 Jun;16(6):259-64.

Partners and pathwaysrepairing a double-strand break.

Author information

1
Rosentiel Basic Medical Sciences Research Center, MS 029 Brandeis University, Waltham, MA 02454-9110, USA. haber@brandeis.edu

Abstract

Double-strand chromosome breaks can arise in a number of ways, by ionizing radiation, by spontaneous chromosome breaks during DNA replication, or by the programmed action of endonucleases, such as in meiosis. Broken chromosomes can be repaired either by one of several homologous recombination mechanisms, or by a number of nonhomologous repair processes. Many of these pathways compete actively for the repair of a double-strand break. Which of these repair pathways is used appears to be regulated developmentally, genetically and during the cell cycle.

PMID:
10827453
[Indexed for MEDLINE]

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