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Parasitol Today. 2000 Jun;16(6):228-32.

Abnormal blood flow and red blood cell deformability in severe malaria.

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Department of Internal Medicine, Tropical Medicine and AIDS, Academic Medical Centre, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands. A.M.Dondorp@AMC.UVA.NL


Obstruction of the microcirculation plays a central role in the pathophysiology of severe malaria. Here, Arjen Dondorp and colleagues describe the various contributors to impaired microcirculatory flow in falciparum malaria: sequestration, rosetting and recent findings regarding impaired red blood cell deformability. The correlation with clinical findings and possible therapeutic consequences are discussed.

[Indexed for MEDLINE]

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