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Emerg Infect Dis. 2000 May-Jun;6(3):265-72.

Genetic variation in Pneumocystis carinii isolates from different geographic regions: implications for transmission.

Author information

1
Centers for Disease Control and Prevention, Atlanta, Georgia 30341-3724, USA. cbb0@cdc.gov

Abstract

To study transmission patterns of Pneumocystis carinii pneumonia (PCP) in persons with AIDS, we evaluated P. carinii isolates from patients in five U.S. cities for variation at two independent genetic loci, the mitochondrial large subunit rRNA and dihydropteroate synthase. Fourteen unique multilocus genotypes were observed in 191 isolates that were examined at both loci. Mixed infections, accounting for 17.8% of cases, were associated with primary PCP. Genotype frequency distribution patterns varied by patients' place of diagnosis but not by place of birth. Genetic variation at the two loci suggests three probable characteristics of transmission: that most cases of PCP do not result from infections acquired early in life, that infections are actively acquired from a relatively common source (humans or the environment), and that humans, while not necessarily involved in direct infection of other humans, are nevertheless important in the transmission cycle of P. carinii f. sp. hominis.

PMID:
10827116
PMCID:
PMC2640877
DOI:
10.3201/eid0603.000306
[Indexed for MEDLINE]
Free PMC Article

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