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Curr Opin Genet Dev. 2000 Jun;10(3):270-4.

Potential mechanisms of mutations that affect neuronal migration in man and mouse.

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1
Division of Neurogenetics, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, Boston, Massachusetts 02115, USA. cwalsh@caregroup.harvard.edu

Abstract

Mutations in the genes that encode filamin-1, Lis1 and doublecortin are responsible for X-linked lissencephaly in man, whereas mutations in the genes that encode Cdk5, its activator p35 and the reelin-signaling pathway disturb migration and architectonic development in mice. To understand the action of genes that control neuronal migration and the phenotype of corresponding defects, it might be as important to consider the positioning of the nucleus as it is to consider the guidance of the leading process.

PMID:
10826984
[Indexed for MEDLINE]
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