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Immunol Today. 2000 Jun;21(6):273-80.

Interleukin 16: implications for CD4 functions and HIV-1 progression.

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Evans Memorial Department of Medicine, Pulmonary Center at Boston University School of Medicine, MA 02118, USA.


In this article, David Center and colleagues clarify the controversies that have emerged over the unique structure of interleukin 16 and its anti-HIV-1 activity. Interleukin 16 is a ligand for CD4, and this implies CD4 acts as a sentinel receptor that can switch CD4+ T cells between immune and inflammatory functions.

[Indexed for MEDLINE]

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