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Immunol Today. 2000 Jun;21(6):273-80.

Interleukin 16: implications for CD4 functions and HIV-1 progression.

Author information

1
Evans Memorial Department of Medicine, Pulmonary Center at Boston University School of Medicine, MA 02118, USA. dcenter@lung.bumc.bu.edu

Abstract

In this article, David Center and colleagues clarify the controversies that have emerged over the unique structure of interleukin 16 and its anti-HIV-1 activity. Interleukin 16 is a ligand for CD4, and this implies CD4 acts as a sentinel receptor that can switch CD4+ T cells between immune and inflammatory functions.

PMID:
10825739
[Indexed for MEDLINE]

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