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Pathophysiology. 2000 Apr;7(1):69-73.

Protection of gastric mucosal integrity by gelatin and simple proline-containing peptides.

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Department of Human and Animal Physiology, School of Biology, Moscow State Lomonosov University, Leninsky Gori 1, Building 12, 119899, Moscow, Russia


We have observed that gelatin as feed supplement protected against ethanol-induced mucosal damages in rats. Intraperitoneally given peptides PG and PGP had similar effects. The increase of mucosal integrity may be connected with the change of microcirculation: the peroral administration of PGP or gelatin given as a feed supplement decreased platelet aggregation.


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