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Acta Biochim Pol. 1999;46(4):971-6.

Protection of cattle against bovine leukemia virus (BLV) infection could be attained by DNA vaccination.

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1
Technical University of Gdańsk, Department of Microbiology, Poland.

Abstract

The bovine leukemia virus (BLV) envelope gene encoding extracellular glycoprotein gp51 and transmembrane glycoprotein gp30 was cloned into a vehicle expression vector under the human cytomegalovirus (CMV) intermediate early promoter. The intramuscular injection of this plasmid vector generated a cellular immune response. Seven out of ten cows vaccinated with the DNA construct resisted a drastic challenge (500 BLV-infected lymphocytes as an infectious dose).

PMID:
10824867
[Indexed for MEDLINE]
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