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Lancet. 2000 May 6;355(9215):1627-32.

Blood coagulation.

Author information

1
Department of Clinical Chemistry, Lund University, University Hospital, Malmö, Sweden. bjorn.dahlback@klkemi.mas.lu.se

Abstract

Under normal circumstances, the coagulation system is balanced in favour of anticoagulation. Thrombin is the key effector enzyme of the clotting cascade. Antagonists of vitamin K inhibit a vitamin-K-dependent post-translational modification of several coagulation proteins, which is required for these proteins to attain a phospholipid-binding conformation. Heparin stimulates the activity of antithrombin, a serine-protease inhibitor. Analysis of knock-out mice has shown the relative importance of the coagulation factors in vivo. Gene therapy may soon be a therapeutic option for inherited deficiencies of factors VIII and IX.

PMID:
10821379
DOI:
10.1016/S0140-6736(00)02225-X
[Indexed for MEDLINE]
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