Send to

Choose Destination
J Neurosci Res. 2000 Jun 1;60(5):587-93.

Dimerization-dependent block of the proapoptotic effect of p75(NTR).

Author information

Program on Aging, The Burnham Institute, La Jolla, CA, USA.


The biochemical mechanism by which neurons become dependent on neurotrophins for survival is unknown. We found previously that the common neurotrophin receptor, p75(NTR), is a mediator of neurotrophin dependence and that this effect requires a novel type of domain dubbed a neurotrophin dependence domain. We report here that, in contrast to other proapoptotic receptors such as Fas, apoptosis induction by p75(NTR) requires monomerization, with dimerization inhibiting the effect. Blocking the proapoptotic effect of the monomer by dimerization requires a distinct domain that lies at the carboxyterminus of p75(NTR). These results define a novel type of domain required for inhibiting apoptosis induction by p75(NTR).

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center