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Curr Opin Chem Biol. 2000 Apr;4(2):207-13.

Dimetallic hydrolases and their models.

Author information

1
Department of Medicinal Chemistry, Faculty of Medicine, Hiroshima University, Japan. ekimura@ipc.hiroshima-u.ac.jp

Abstract

Recent mechanistic studies of Fe3+/M2+ purple acid phosphatase present conflicting pictures about the roles of the metals. Recent model studies with Co3+/Co3+ and Fe3+/Fe3+ complexes have supported each conflicting mechanism for phosphate hydrolysis. With dizinc and trizinc complexes, the competitive binding of hydroxyl and phosphate substrates has been demonstrated.

PMID:
10819596
[Indexed for MEDLINE]

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