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Curr Opin Cell Biol. 2000 Apr;12(2):244-9.

BMP, Wnt and Hedgehog signals: how far can they go?

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Oregon Health Sciences University, School of Medicine, Department of Cell and Developmental Biology, Portland 97201, USA.


Wnt, Hedgehog and bone morphogenetic proteins function as either short-range or long-range signaling molecules depending on the tissue in which they are expressed. In the past year, filapodia-like cytoplasmic extensions, cell-surface proteogylcans and/or extracellular binding proteins have been identified that may enable these molecules to signal at a distance. Furthermore, recent studies suggest that variations in the signaling range of these molecules may be due to tissue-specific differences in intracellular processing or tissue-restricted expression of binding proteins.

[Indexed for MEDLINE]

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