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Ann N Y Acad Sci. 2000 Apr;903:345-52.

Animal model of Alzheimer-like vascular pathology and inflammatory reaction.

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Department of Anatomy, College of Medicine, University of South Florida, Tampa 33612, USA.


This in vivo animal model of vascular inflammatory reaction facilitates morphologic and hemodynamic analyses of leukocyte-endothelial interaction and can be monitored by video microscopy and electron microscopy. The model has served as a rapid means to explore the deleterious vascular actions and inflammatory response to the cytokines tumor necrosis factor, interleukin-1 and amyloid-beta, as well as the protective effects of superoxide dismutase, estrogen, and cytokine antagonists.

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