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Ned Tijdschr Geneeskd. 2000 Apr 29;144(18):847-50.

[Scrotal testosterone patches: a good addition to therapeutic options for hypogonadal men].

[Article in Dutch]

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Academisch Ziekenhuis Vrije Universiteit, afd. Endocrinologie, Amsterdam.



To report the experience with treatment of hypogonadal men with the scrotal application of testosterone patches.


Prospective and descriptive.


In 12 unselected hypogonadal men (aged 27-58 years; serum concentration of testosterone < 10 nmol/l) who complained of adverse effects of oral androgen treatment, the treatment was changed to scrotal application of testosterone patches (Testoderm). First the androgen substitution was stopped for 6 weeks. Follow-up was 4-5 years, during which regular laboratory tests were carried out, the patients filling in questionnaires regarding their general mood and the frequency of sexual feelings/activities.


Testosterone levels reached physiological values and a beneficial effect was observed on general mood and sexual functioning. These effects remained stable throughout the entire period of 4-5 years of study. Skin reactions occurred in 2 men. Dihydrotestosterone levels increased to supraphysiological values. Other clinical, biochemical and haematological parameters did not reveal any detrimental effects. The patch, which should be applied to a dry and shaved scrotal skin, was a satisfying androgen replacement therapy for more than 4 years in 7 out of 12 men.


In this open study in hypogonadal men with complaints about previous testosterone therapy, scrotal testosterone patches were a useful therapy, leading to the testosterone levels in the physiological range.

[Indexed for MEDLINE]

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