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Org Lett. 2000 Mar 9;2(5):709-12.

Pairwise use of complexity-generating reactions in diversity-oriented organic synthesis.

Author information

1
Howard Hughes Medical Institute, Department of Chemistry & Chemical Biology, Harvard Institute of Chemistry & Cell Biology, Harvard University, Cambridge, Massachusetts 02138, USA.

Abstract

[reaction: see text] Two pairs of complexity-generating reactions with an essential product-substrate relationship along a synthetic pathway are demonstrated. This pathway illustrates a key element in a planning algorithm for diversity-oriented synthesis. This element facilitates the efficient synthesis of structurally complex compounds, and it can be integrated with ones that provide structurally diverse compounds.

PMID:
10814416
DOI:
10.1021/ol005574n
[Indexed for MEDLINE]

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