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Dis Colon Rectum. 2000 Jan;43(1):105-8.

Hepatoid adenocarcinoma of the rectum arising in ulcerative colitis: report of a case.

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  • 1Department of Pathology, Histology, and Cytology, F. Addarii Institute, S. Orsola Malpighi Hospital, Bologna, Italy.


We report a case of intestinal hepatoid adenocarcinoma, confirmed by albumin m-RNA in situ hybridization, with subsequent metastatic spread to the liver in a male with a long-standing history of ulcerative colitis. This novel finding strongly suggests that ulcerative colitis can lead not only to conventional adenocarcinomas but also to hepatoid adenocarcinoma and highlights the mimicry of hepatocellular carcinoma by metastatic hepatoid adenocarcinoma liver nodules.

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