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Biol Psychiatry. 2000 May 1;47(9):830-5.

Reactivity to a 35% CO2 challenge in healthy first-degree relatives of patients with panic disorder.

Author information

1
Department of Psychiatry, University Maastricht, The Netherlands.

Abstract

BACKGROUND:

The effects of a 35% CO2 challenge were examined in healthy first-degree relatives of panic disorder patients and in healthy control subjects matched for age and gender.

METHODS:

One single inhalation of a 35% CO2/65% O2 challenge was administered to 50 first-degree relatives of panic disorder patients and 50 control subjects.

RESULTS:

The first-degree relatives were more reactive to the 35% CO2 challenge than the control subjects.

CONCLUSIONS:

These findings indicate that being a member of a family with a panic disorder patient is, in itself an important factor in CO2 hypersensitivity among subjects who have never experienced a panic attack. Both panic disorder patients and their first-degree relatives have a tendency to be more reactive to the CO2 challenge.

PMID:
10812042
[Indexed for MEDLINE]

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