Format

Send to

Choose Destination
Hematol Oncol Clin North Am. 2000 Apr;14(2):339-53.

A comprehensive review of vitamin K and vitamin K antagonists.

Author information

1
Division of Vitamin K Research, University of Maastricht, The Netherlands.

Abstract

For more than 60 years, vitamin K-dependent proteins have been known to play an important role in regulating blood coagulation. During recent years it has become clear, however, that vitamin K is also involved in other physiologic processes, including bone metabolism and vascular biology. Because the vitamin K requirement of bone and vessel wall is higher than that of the liver (where the clotting factors are produced) recommended daily allowance (RDA) values for K vitamins must be redefined. According to the new definition, a substantial part of the population is mildly deficient in vitamin K, and at later ages this deficiency may contribute to increased bone fracture risk, arterial calcification, and cardiovascular disease.

PMID:
10806559
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center