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J Antibiot (Tokyo). 2000 Feb;53(2):158-62.

Enhancement of the antifungal activity of rapamycin by the coproduced elaiophylin and nigericin.

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1
Biology Department, Massachusetts Institute of Technology, Cambridge 02139, USA.

Abstract

Streptomyces hygroscopicus ATCC 29253 produces rapamycin, elaiophylin and nigericin. Although elaiophylin has no activity against Candida albicans ATCC 11651, it markedly enhances rapamycin's antifungal activity. Nigericin has only weak activity on its own but it also enhances rapamycin action. Surprisingly, elaiophylin does not enhance nigericin activity on C. albicans.

PMID:
10805576
DOI:
10.7164/antibiotics.53.158
[Indexed for MEDLINE]
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