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Cytokine. 2000 Apr;12(4):417-21.

Dual effect of IL-4 on resistance to systemic gram-negative infection and production of TNF-alpha.

Author information

1
Department of Experimental Medicine, University of Perugia, Italy.

Abstract

To determine the effect of interleukin 4 (IL-4) administration in a live sepsis model characterised by high-level production of tumour necrosis factor a (TNF-alpha), mice infected systemically with lethal or sublethal inocula of Pseudomonas aeruginosa were given the recombinant cytokine at different times before infection. Improved survival and decreased TNF-alpha production were observed in lethally infected mice treated with the cytokine 1 day before challenge. In contrast, increased mortality and overproduction of TNF-alpha were observed in sublethally infected mice given IL-4 at the time of infection.

PMID:
10805227
DOI:
10.1006/cyto.1999.0576
[Indexed for MEDLINE]

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