Format

Send to

Choose Destination
See comment in PubMed Commons below
Development. 2000 Jun;127(11):2317-22.

Adult insulin- and glucagon-producing cells differentiate from two independent cell lineages.

Author information

1
Department of Morphology, University of Geneva Medical School, rue Michel-Servet, Switzerland. pedro.herrera@medecine.unige.ch

Abstract

To analyze cell lineage in the pancreatic islets, we have irreversibly tagged all the progeny of cells through the activity of Cre recombinase. Adult glucagon alpha and insulin beta cells are shown to derive from cells that have never transcribed insulin or glucagon, respectively. Also, the beta-cell progenitors, but not alpha-cell progenitors, transcribe the pancreatic polypeptide (PP) gene. Finally, the homeodomain gene PDX1, which is expressed by adult beta-cells, is also expressed by alpha-cell progenitors. Thus the islet alpha- and beta-cell lineages appear to arise independently during ontogeny, probably from a common precursor.

PMID:
10804174
[Indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Support Center