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J Infect Dis. 2000 May;181 Suppl 2:S309-16.

Organization and expression of calicivirus genes.

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1
Virology Group, University Medical School, Southampton General Hospital, Southampton, SO16 6YD, UK. inc@soton.ac.uk.

Abstract

The application of molecular techniques to the characterization of caliciviruses has resulted in an extensive database of sequence information. This information has led to the identification of 4 distinct genera. The human enteric caliciviruses have been assigned to 2 of these genera. This division is reflected not only in sequence diversity but in a fundamental difference in genome organization. Complete genome sequences are now available for 5 enteric caliciviruses and demonstrate that human and animal enteric caliciviruses are phylogenetically closely related. Currently, there is no cell culture system for the human viruses; therefore, studies have relied on heterologous expression and in vitro systems. These studies have shown that in both human and animal viruses the viral nonstructural proteins are produced from a polyprotein precursor that is cleaved by a single viral protease. The purpose of this article is to provide an overview of the current knowledge of genome structure and gene expression in the enteric caliciviruses.

PMID:
10804143
DOI:
10.1086/315575
[Indexed for MEDLINE]
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