A short description of basic types of high pressure apparatuses is presented in view of their application in a research in the biosciences. General tendencies in an evolution of characteristic inter-atomic bonds and their changes under high pressure are shortly reviewed. A complex behaviour of organic macromolecular compounds under pressure is demonstrated by the effects of pressure on proteins (including p--T diagram of proteins denaturation). In consequence, an effect of pressure on the simplest micro-organisms is mentioned and relevant critical pressures of sterilization are presented. Trends in a future application of results of the pressure research in biosciences are discussed.